Categorical variables were reported as percentage and the statistical analysis done by use of Chi-square test. All P values reported analyses were two-tailed. The analysis was done on intention-to-treat basis. The base line parameters of both the group has been shown in Table 1.
However, on comparison failed show any statistical difference at 3 and 6 weeks of treatment [ Table 3 ]. Escitalopram and desvelafaxine were both safe and well-tolerated and there was not much difference between the two groups as evident from UKU-scale [ Table 4 ]. Escitalopram and desvelafaxine were both safe and well-tolerated and there was not much difference between the two groups as far the effect on various biochemical parameters was concerned [ Table 5 ].
In the present study, it was seen that escitalopram-reduced depression levels with a decrease from the baseline value HAM-D from 3 weeks onward till the end of the study.
The above findings are in concurrence with various published reports in which these drugs, individually were efficacious in decreasing depression and anxiety in comparison to placebo.
A similar reduction in depression by escitalopram is also reported by Burke et al. Rapaport et al. Moore et al. There were more treatment responders with escitalopram In the present study, it was seen that desvenlafaxine produced a decrease from the baseline value of HAM-D from 3 weeks onward till the end of the study, that is, at 6 weeks.
Desvenlafaxine has also been shown to cause a significant reduction in depression in several studies. Our results are almost in accordance to those put forth by Soares et al. Reductions in HAM-D 17 total score at acute phase end point were similar for desvelafaxine and escitalopram-treated women Limited studies have directly compared the efficacy of escitalopram with desvenlafaxine in treatment of major depression, otherwise escitalopram has been compared with class SNRI's in other studies.
Kornstein et al. In the present study, it was seen that escitalopram produced a decrease from the baseline value of HAM-A, from 3 weeks onward till the end of the study, that is, at 6 weeks indicating additional antianxiety activity. Similar reductions in anxiety by escitalopram were put forth by Malin et al. It also showed efficacy in treating panic disorder and generalized and social anxiety disorders. Bandelow et al. Similarly, escitalopram was shown significantly more effective compared to placebo in treating both anxiety symptoms and the entire depression in the total depressive population, as well as in depressive patients with a high degree of anxiety by Cyril and Jaromir.
In the present study, it was seen that desvenlafaxine also produced a decrease from the baseline value of HAM-A, from 3 weeks onward till the end of the study, that is, at 6 weeks.
Similar reductions in anxiety by desvenlafaxine were put forth by Tourian et al. Similar results are shown by Soares et al. In the present study, it was seen that escitalopram produced a decrease from the respective baseline value of CGI from 3 weeks onward till the end of the study, that is, at 6 weeks. In the present study, it was seen that desvenlafaxine also produced a decrease from the respective baseline value of CGI from 3 weeks onward till the end of the study, that is, at 6 weeks.
Similar reductions in CGI were seen in other studies also. Similar results were seen by Soares et al. In the present study, escitalopram and desvenlafaxine were safe and well-tolerated. UKU scale is used to evaluate side effects and the values are 0. There was no other discontinuation due to any other reasons including adverse effects in the present study. Similar side effect profile was put forth by Soares et al.
The present study does have some limitations. First, it is a short-term study with less number of patients andeffect of small sample size cannot be ruled out on results of the study. The present study demonstrated almost similar efficacy and safety in reducing depression and anxiety with both escitalopram and desvenlafaxine, but clinical superiority of one drug over the other cannot be definitely be concluded due to small sample size.
Minor weight gain has been reported pounds. Zoloft does tend to cause diarrhea more when compared to other antidepressants. Mental Health Daily reported that in , Desyrel was prescribed more than 22 million times.
The generic version is Trazodone which is used for major depressive disorder and insomnia associated with depression. It also treats anxiety disorders and alcohol addiction. This SSRI antidepressant works by restoring the balance or serotonin in the brain, it improves mood, appetite, and energy levels. Anxiety and insomnia related to depression are also reduced. For depression, dosage should be mg per day. The dose can increase to mg per day with dosages being divided up throughout the day.
The maximum dose for severely depressed patients can be administered to mg per day. For those looking to use it for insomnia, it should given in much smaller doses daily. When reviewed , six out of ten people who were being prescribed antidepressants for the first time said it worked for them. In , there were over 24 million prescriptions written for Prozac. The generic version is fluoxetine which is good for treating depression and anxiety. It gives people more energy than other antidepressants which may not work well for someone with insomnia as well as depression.
That being said, for those with low energy, it can be helpful. Fluoxetine treats many mental health issues which includes depression, OCD, and panic disorders. Prozac can take more time to help with symptoms of depression compared to other SSRIs. It can also lower your libido. Paroxetine is a generic brand of antidepressants that includes Paxil, Pexeva, and Brisdelle. Paroxetine treats anxiety and depression.
The issues is that is causes more undesirable side effects than other SSRI medications. It has a greater likelihood of decreasing the libido and may even prevent ejaculation. All the brand names that have paroxetine help to improve your mood. You will have a greater appetite and energy level. It should effectively help you to sleep also. It can help decrease any fear or anxiety one might have. It has also been shown to reduce anxiety attacks. Others also said it made them gain weight.
Luvox is the brand name that primarily treats obsessive-compulsive disorder. The generic name is fluvoxamine, which is an SSRI. There is an immediate release and extended release version of Luvox CR. It can effect your sex drive however. Luvox CR is used for children with OCD and can be used for depression if other antidepressants are causing unwanted side effects. In the reviews , people with anxiety and depression says it stabilized their moods.
In , there were over 12 million prescriptions written for Effexor. The generic version is venlafaxine and differs from other antidepressants. It is a serotonin and norepinephrine reuptake inhibitor antidepressant. It works to regulate your mood and allows you to feel more relaxed. This is why it can be used for both anxiety and depression. It is also used for panic disorder. The belief is that it changes dopamine and norepinephrine activity in the brain.
This regulates your mood and relieves symptoms of depression. Notably, it has less sexual side effects than other medications for depression. There are stimulant effects with bupropion so someone may feel energized.
This can be helpful for those with depression but it could cause insomnia or anxiety. The drug has helped people suppress their appetite and can help you to stop smoking.
Wellbutrin is available in immediate release tablets in 75 mg and mg doses. There is also a sustained release sold in mg and mg formulas. Generally, those who reviewed Wellbutrin said their intrusive thoughts diminished but anxiety was heightened. Abilify, also known as aripiprazole, is prescribed to those with schizophrenia, depression, and bipolar disorder.
It is another atypical antipsychotic that stabilizeds dopamine and serotonin levels in the brain. This helps to control thoughts and positively affects your mood.
The drug primarily relieves psychotic symptoms and manic episodes. When compared to other antipsychotics, it does come with less side effects. Studies have found that Abilify is helpful for depression, especially for women. If symptoms are not dissipating when using an antidepressant, your physician may also incorporate this antipsychotic. Avoid alcohol when taking Pristiq or Effexor.
If Pristiq is taken with a medication that is metabolized by an enzyme called cytochrome P 2D6, the other medication may build up to levels that are too high and can become toxic. Dosage adjustment may be required. Effexor does not have this interaction. This is not a full list of drug interactions.
Consult your healthcare provider for a complete list of drug interactions. All antidepressants, including Pristiq and Effexor, have a boxed warning of suicidality. A boxed warning is the most serious warning required by the FDA. Children, adolescents, and young adults up to 24 years old who take antidepressant drugs have an increased risk of suicidal thoughts and behavior.
All patients on antidepressant medications should be carefully monitored. Pristiq is an SNRI antidepressant. Pristiq treats depression in adults.
The generic name is desvenlafaxine. Effexor is also an SNRI antidepressant. Effexor treats depression in adults. Effexor XR extended-release treats depression, social anxiety disorder, panic disorder, and generalized anxiety disorder.
The generic name of Effexor is venlafaxine. The medications are very similar. When Effexor is metabolized in the body, it turns into desvenlafaxine, the active ingredient of Pristiq.
The two drugs are similar but have some differences, such as in dose, price, side effect rates of occurrence, and drug interactions.
Both drugs are similar in terms of efficacy. Your healthcare provider can guide you regarding which drug may be appropriate for you. Consult your healthcare provider for advice. He or she will weigh the benefits of taking an antidepressant vs. Neonates exposed to certain antidepressants, including SNRIs or SSRIs selective serotonin reuptake inhibitors like Prozac , in the third trimester of pregnancy, have developed serious complications.
Pristiq or Effexor should not be taken with alcohol because the combination may increase the risk of respiratory depression slowed breathing, not getting enough oxygen and increase sedation and drowsiness, and impair alertness. The combination can also worsen anxiety and depression.
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